Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.
Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.
Episodes
54 episodes
44. Sulfur Intolerace Explained: What Is It? Why Does It Happen? How Does It Increase Histamine?
Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better?In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, g...
Q&A. Why Does My Anxiety Get Worse at Night or Wake Me Up at 3am?
Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts?In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-t...
43. Blood Sugar & Anxiety in Women: The Hidden Cause of Chronic Anxiety
Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results?In this episode of The Histamine Well Podcast, Joanne uncovers one of the most overlooked root causes of anxiety in ...
Q&A. Why Do I Still Have Inflammation When My CRP & ESR Are Normal?
If your blood tests are “normal”… why do you still feel inflamed?In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can...
42. Why Your Hormones Haven't Improved Despite Treatment - The Role of Inflammation, Histamine & Methylation
In this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface.Drawing on clinical observation and biochemistry, Joa...
Q&A. Are Bioidentical Hormones Actually Natural?
Are bioidentical hormones truly “natural”—or is that just clever marketing?In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioi...
41. Can’t Tolerate HRT? The Hidden Reason Most Women Miss
Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women.Joanne Kennedy shares a clinical case study s...
Q&A. How Does Sulforaphane Work in the Body? Hint: It Switches On Your Protective Genes
In this Q&A Clarity Session of The Histamine Well Podcast, naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway, often referred to as the body’s “master switch” for ...
40. The GEMM Protocol: A Deeper Approach To Why Your Gut Isn't Healing - And What To Do About It
In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the...
Q&A. Should I Take Antibiotics for SIBO?
In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO?The truth is—it depends.In this episode, Joanne breaks down the two distinct...
39. Why Does Your SIBO Keep Coming Back? (And What Most Treatments Miss)
Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction?In this episode of The Histamine Well Podcast, Joanne explains why...
Q&A. How Is Methylation Connected to Mental Health?
In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance...
38. Helicobacter pylori, Low Stomach Acid & Histamine: The Gut Cascade Explained
In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.H. pylori pr...
Q&A. What Type of Magnesium Should I Take?
In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Lear...
37. Candida and Histamine: Why Fungal Overgrowth Keeps Coming Back
In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms.She explains how fungal-driven gut inflammation increases hi...
Q&A. Should I Be Taking Antihistamines Long Term?
In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn...
36. Less Is More: Why Over-Treating Mold & Food Intolerance Makes Things Worse
In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure.After years of misdiagnosis and...
Q&A. If I have MTHFR Does it Mean I Can't Detox?
In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what...
35. Understanding MARCoNS and Its Impact on Inflammation, Histamine, and Chronic Symptoms
In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic ...
34. Vitamin B12 Explained: Forms, Methylation, Homocysteine & Absorption
In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health.Together, they unpack the complex biochemistry of Vitamin B12, ex...
33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation
In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and in...
32. Hormone Replacement Therapy in Perimenopause: Interview with Rachel Schaefer
Are your hormones out of balance? In this episode of The Histamine Well Podcast, Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine, to demystify perimenopause and the role of Hormone Replacement The...
31. How to Protect Your Home from Mold and EMF Exposure with Building Biologist Jo Lia
Is your home secretly affecting your health? In this episode of The Histamine Well Podcast, Joanne’s colleague Melanie Peers sits down with Building Biologist Jo Lia to uncover the hidden dangers of mold, electromagnet...
30. Hydrogen Sulfide SIBO Explained: Symptoms, Testing & Treatments with Rosaria Nithart
In this episode of The Histamine Well Podcast, Joanne sits down with Rosaria Nithart, a French-based naturopath specializing in digestive health, to uncover the complexities of Hydrogen Sulfide SIBO—one of the most misunderstood ...
29. Healing Chronic Illness Through Nervous System Regulation with Jacqui Raadschelders
In this episode of The Histamine Well Podcast, Joanne Kennedy sits down with physiotherapist and neuro-rehabilitation specialist Jacqui Raadschelders to explore the link between nervous system dysregulation and chronic illness.Y...