Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.
Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.
Episodes
49 episodes
Q&A. Are Bioidentical Hormones Actually Natural?
Are bioidentical hormones truly “natural”—or is that just clever marketing?In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioi...
•
3:00
41. Can’t Tolerate HRT? The Hidden Reason Most Women Miss
Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women.Joanne Kennedy shares a clinical case study s...
•
Episode 41
•
12:03
Q&A. How Does Sulforaphane Work in the Body? Hint: It Switches On Your Protective Genes
In this Q&A Clarity Session of The Histamine Well Podcast, naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway, often referred to as the body’s “master switch” for ...
•
3:51
40. The GEMM Protocol: A Deeper Approach To Why Your Gut Isn't Healing - And What To Do About It
In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the...
•
Episode 40
•
51:51
Q&A. Should I Take Antibiotics for SIBO?
In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO?The truth is—it depends.In this episode, Joanne breaks down the two distinct...
•
5:09
39. Why Does Your SIBO Keep Coming Back? (And What Most Treatments Miss)
Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction?In this episode of The Histamine Well Podcast, Joanne explains why...
•
Episode 39
•
13:50
Q&A. How Is Methylation Connected to Mental Health?
In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance...
•
6:07
38. Helicobacter pylori, Low Stomach Acid & Histamine: The Gut Cascade Explained
In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.H. pylori pr...
•
Episode 38
•
13:42
Q&A. What Type of Magnesium Should I Take?
In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Lear...
•
7:17
37. Candida and Histamine: Why Fungal Overgrowth Keeps Coming Back
In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms.She explains how fungal-driven gut inflammation increases hi...
•
Episode 37
•
14:12
Q&A. Should I Be Taking Antihistamines Long Term?
In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn...
•
4:23
36. Less Is More: Why Over-Treating Mold & Food Intolerance Makes Things Worse
In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure.After years of misdiagnosis and...
•
Episode 36
•
38:45
Q&A. If I have MTHFR Does it Mean I Can't Detox?
In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what...
•
5:38
35. Understanding MARCoNS and Its Impact on Inflammation, Histamine, and Chronic Symptoms
In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic ...
•
Episode 35
•
9:50
34. Vitamin B12 Explained: Forms, Methylation, Homocysteine & Absorption
In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health.Together, they unpack the complex biochemistry of Vitamin B12, ex...
•
Episode 34
•
48:04
33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation
In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and in...
•
Episode 33
•
11:18
32. Hormone Replacement Therapy in Perimenopause: Interview with Rachel Schaefer
Are your hormones out of balance? In this episode of The Histamine Well Podcast, Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine, to demystify perimenopause and the role of Hormone Replacement The...
•
Episode 32
•
1:13:46
31. How to Protect Your Home from Mold and EMF Exposure with Building Biologist Jo Lia
Is your home secretly affecting your health? In this episode of The Histamine Well Podcast, Joanne’s colleague Melanie Peers sits down with Building Biologist Jo Lia to uncover the hidden dangers of mold, electromagnet...
•
Episode 31
•
1:01:06
30. Hydrogen Sulfide SIBO Explained: Symptoms, Testing & Treatments with Rosaria Nithart
In this episode of The Histamine Well Podcast, Joanne sits down with Rosaria Nithart, a French-based naturopath specializing in digestive health, to uncover the complexities of Hydrogen Sulfide SIBO—one of the most misunderstood ...
•
Episode 30
•
39:02
29. Healing Chronic Illness Through Nervous System Regulation with Jacqui Raadschelders
In this episode of The Histamine Well Podcast, Joanne Kennedy sits down with physiotherapist and neuro-rehabilitation specialist Jacqui Raadschelders to explore the link between nervous system dysregulation and chronic illness.Y...
•
Episode 29
•
46:51
28. Oxalates, Adrenal Fatigue & Blood Sugar Imbalance: Tracy’s Journey to Healing
In this episode of The Histamine Well Podcast, Joanne is joined by colleague Melanie and patient Tracy, who shares her powerful story of navigating the challenges of oxalates, histamine intolerance, adrenal fatigue, and blood sugar imb...
•
Episode 28
•
1:08:58
27. Why Blood Tests & Functional Medicine Tests Aren’t the Full Story: Gut, Histamines, Genes, Hormones & More!
In this episode of The Histamine Well Podcast, host Joanne Kennedy and guest Mariella Gebhardt unpack the nuances of medical testing in functional medicine—and why lab results alone don’t always tell the full story.From histamin...
•
Episode 27
•
47:16
26. Mold & Chronic Illness: Symptoms, Testing, and Detox Strategies with Melanie Peers
Could mold be the missing link in your chronic health puzzle?In this episode of The Histamine Well Podcast, Joanne speaks with Melanie Peers about the hidden impact of mold illness and how it can silently dr...
•
Episode 26
•
54:05
25. Energy Healing Essentials for Perimenopause: A Discussion with Claire Tait
Perimenopause isn’t just a physical transition — it’s an emotional, spiritual, and energetic shift. In this empowering episode of The Histamine Well Podcast, Joanne speaks with Claire Tait, a holistic kinesiologist and intuitive energy healer, ...
•
Episode 25
•
1:02:01
24. Histamine & Anxiety – How High Histamine Triggers Fight-or-Flight Symptoms
Can histamine be the hidden reason behind your anxiety?In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methyla...
•
Episode 24
•
31:10